We previously discovered that p53 extensively binds to transcriptional regulatory sequences known as enhancers (Sammons et al, 2015). Enhancers are DNA sequences critical for temporal and spatial control of gene expression. We believe that p53 binding and regulation of enhancers is a fundamental function for p53 across cell types.
Shared Gene Targets of the ATF4 and p53 Transcriptional Networks Baniulyte, et al. Molecular and Cellular Biology 2023
Locally acting transcription factors regulate p53-dependent cis-regulatory element activity Catizone, et al. Nucleic Acids Research 2020
p63 establishes epithelial enhancers at critical craniofacial development genes Lin-Shiao E, et al. Science Advances, 2019