We study the interplay between chromatin and transcription factors. Chromatin structure influences the interaction of transcription factors with DNA, a regulatory mechanism with implications in almost every developmental process and disease state. The activity of sequence-specific transcription factors also directly informs local and long-range chromatin structure.
The lab uses the p53 family of transcription factors as a model to study different facets of the interaction between chromatin structure, transcription factor biology, and cell fate decisions. We use classical genetic and molecular techniques along with genome and systems-wide approaches to study how chromatin and p53 family members interact with and influence each other.