Morgan Sammons

Principal investigator
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masammonsobfuscate@albany.edu

I'm an Assistant Professor at State University of New York at Albany in the Department of Biology. I study the role of chromatin structure on gene expression using the p53 family as a model. How does chromatin regulate transcriptional output? How does p53 binding at enhancers control downstream transcription? Do other transcription factors regulate chromatin structure and enhancer activity to support or inhibit p53 tumor suppression?

I teach the undergraduate course ABIO 329: Genetics of Human Disease at the University at Albany, State university of New York.

Papers

Comparison of genotoxic vs. non-genotoxic stabilization of p53 provides insight into parallel stress-responsive transcriptional networks

Disruption of TET2 promotes the therapeutic efficacy of CD19-targeted T cells

Cell type-dependent control of p53 transcription and enhancer activity by p63

The transcription factor Tfap2e/AP-2ε plays a pivotal role in maintaining the identity of basal vomeronasal sensory neurons

Lysine methylation represses p53 activity in teratocarcinoma cancer cells.

Epigenetic stability of exhausted T cells limits durability of reinvigoration by PD-1 blockade

A rare DNA contact mutation in cancer confers p53 gain-of-function and tumor cell survival via TNFAIP8 induction.

A chromatin-focused siRNA screen for regulators of p53-dependent transcription

Gain-of-function p53 mutants co-opt chromatin pathways to drive cancer growth

Mitotic Stress Is an Integral Part of the Oncogene-Induced Senescence Program that Promotes Multinucleation and Cell Cycle Arrest.

TP53 engagement with the genome occurs in distinct local chromatin environments via pioneer factor activity

Posts

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